A single dose of the Pfizer / BioNTech coronavirus vaccine can block 75% of asymptomatic infectionssuggested a study on UK National Health Service (NHS) workers.
Asymptomatic evaluation by staff at Addenbrooke Hospital in Cambridge showed that the number of people who tested positive decreased from 0.8% to 0.2% 12 days after the first injection.
The findings labeled by local authorities as “very impressive” are another sign that Britain’s bid to delay the second dose in a bid for broader and faster vaccination coverage has paid off.
As they explained, curbing asymptomatic infections is crucial to prevent outbreaks of new infections from growing unknowingly, because people who don’t feel sick are less likely to isolate themselves.
Numerous studies had indicated that a single injection of the jab from the US company Pfizer and the German BioNTech prevented serious illness and death, but it was not clear to what extent it blocked asymptomatic spread. Research has also suggested that the Oxford University / AstraZeneca inoculant stops more than 60 percent of asymptomatic cases.
The study, led by the University of Cambridge, analyzed thousands of weekly COVID diagnostic tests at the Cambridge University Hospitals NHS Foundation Trust during January.
In this analysis the scientists found that 26 of 3,252 swabs (0.8 percent) of unvaccinated workers tested positive for their swabs, compared to four of 1,989 (0.2 percent) in personnel tested 12 days or more after their vaccination.
The study, which has not yet been peer-reviewed, also found that asymptomatic infection was cut in half in those vaccinated for less than 12 days, suggesting that immunity kicks in rapidly in many cases.
Independent experts reacting to prepress praised the findings, saying they indicated the UK was heading towards a “much more hopeful future”.
For the teacher Jonathan Ball, molecular virologist at the University of Nottingham, “Seeing such a reduction in infection rates after just one dose of the Pfizer vaccine is very impressive and shows that vaccination really does offer a way out of current restrictions and a much brighter future.”.
“It will be important to understand whether the reduction in the risk of infection was manifested in all the exposure risk groups included in the study, but nonetheless, this is still excellent news,” he added to Daily Mail.
According to what was explained by the doctor Simon Clarke, associate professor of cell microbiology at the University of Reading, “In working-age adults, the Pfizer-BioNTech vaccine has good efficacy in preventing asymptomatic COVID-19 infection. This is really important if we want to decrease the amount of spread by people who do not know they are infected ”.
“While this is very encouraging, no data was provided to show how long the effect will last and continued monitoring is required in case this protection is diminished”, He pointed.
He added that the study “arose after studying NHS personnel and it appears that an assessment of their pre-existing immune status has not been carried out, which could have been higher than in the general population given the probability of exposure from healthcare workers. at work”. Pre-exposure to the coronavirus before receiving a dose appears to elicit a stronger immune response to the vaccine.
Nevertheless, Clarke cautioned that “it is also important to remember that these findings cannot automatically be extended to all other vaccines.”. Over a two-week period between January 18 and January 31, the Cambridge researchers examined similar numbers of vaccinated and unvaccinated personnel using around 4,400 PCR tests per week. A positive PCR swab would indicate that even someone who is vaccinated has fragments of the virus in their nose or throat that could transmit the disease.
Reducing the spread is essential to achieve “herd immunity”, when so many people are immune that a disease disappears. The results were then separated to identify unvaccinated personnel and personnel who had been vaccinated more than 12 days before the test, when immunity was activated.
It is because of that When the team included symptomatic healthcare workers, their analyzes showed similar reductions. About 56 of 3,282 (1.7 percent) of unvaccinated healthcare workers tested positive, compared with eight of 1,997 (04 percent) at 12 days or more after vaccination, a four-fold reduction.
The researchers published their data prior to peer review due to the urgent need to share information related to the pandemic.
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